Protein Details: Voltage-gated potassium channel subunit beta-3

Protein ID

ICDB_Pro_0715

Protein Name

Voltage-gated potassium channel subunit beta-3

Gene Name

Kcnab3

Organism

Mus musculus (Mouse)

Length

249 amino acids

AlphaFoldDB

AF-P97382-F1-model_v4.pdb

Function

Accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit. Alters the functional properties of Kv2.2 but not Kv2.1

Sequence

MSRGYGLIFSLKVVFTFLSLPHPPGLQGSLDRLQLEYVDIVFANRSDPNSPMEEIVRAMTYVINQGLALYWGTSRWSAAEIMEAYSMARQFNLIPPVCEQAENHFFQREKVEMQLPELYHKIGVGSVTWSPLACGLITSKYDGRVPDTCKATVKGYQWLKEKVQSEEGKKQQARVMDLLPTARQLGCTVGQLAIAWCLRSEGVSSVLLGVSSAEQLMEHLGSLQVLSQLTPQTVVEIDALLGNKSHSKK

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

44;74;75;100;129;130;131;132;133;140;150;209;211;215;218

Disease

Location

Strong expression in brain; with highest levels in neocortical and allocortical regions; hippocampus; olfactory bulb and cerebellum. Also strong in kidney. Weak expression in lung; skeletal muscle and heart.

DOI ID

10.1074/jbc.271.42.26341